Molecular pharmacology of endothelin converting enzymes

AJ Turner, LJ Murphy - Biochemical pharmacology, 1996 - Elsevier
A critical processing step in endothelin biosynthesis is the conversion of the intermediate
“big endothelin” to its biologically active product catalysed by endothelin converting enzyme …

Metallopeptidase inhibitors induce an up-regulation of endothelin-converting enzyme levels and its redistribution from the plasma membrane to an intracellular …

K Barnes, K Shimada, M Takahashi… - Journal of Cell …, 1996 - journals.biologists.com
Endothelinconverting enzyme is a phosphoramidonsensitive membrane metallopeptidase
that catalyses the final step in biosynthesis of the potent vasoactive endothelin peptides …