Indazole scaffold: A generalist for marketed and clinical drugs
Y Cao, C Luo, P Yang, P Li, C Wu - Medicinal Chemistry Research, 2021 - Springer
More and more attention has been paid to the structurally diverse indazole analogs in recent
years which are widely present in numerous commercially available drugs. Indazole …
years which are widely present in numerous commercially available drugs. Indazole …
Indazole as a privileged scaffold: the derivatives and their therapeutic applications
J Qin, W Cheng, YT Duan, H Yang… - Anti-Cancer Agents in …, 2021 - ingentaconnect.com
Background: Heterocyclic compounds, also called heterocycles, are a major class of organic
chemical compound that plays a vital role in the metabolism of all living cells. The …
chemical compound that plays a vital role in the metabolism of all living cells. The …
Rational approaches towards lead optimization of kinase inhibitors: the issue of specificity
P Badrinarayan, GN Sastry - Current pharmaceutical design, 2013 - ingentaconnect.com
Kinases are one of the most popular classes of drug targets as they are involved in signal
transduction pathways, which are wired through a phosphotransfer cascade and elicit a …
transduction pathways, which are wired through a phosphotransfer cascade and elicit a …
Multiple target drug cocktail design for attacking the core network markers of four cancers using ligand-based and structure-based virtual screening methods
YH Wong, CL Lin, TS Chen, CA Chen, PS Jiang… - BMC Medical …, 2015 - Springer
Background Computer-aided drug design has a long history of being applied to discover
new molecules to treat various cancers, but it has always been focused on single targets …
new molecules to treat various cancers, but it has always been focused on single targets …
Classification of FLT3 inhibitors and SAR analysis by machine learning methods
Y Zhao, Y Tian, X Pang, G Li, S Shi, A Yan - Molecular Diversity, 2023 - Springer
FMS-like tyrosine kinase 3 (FLT3) is a type III receptor tyrosine kinase, which is an important
target for anti-cancer therapy. In this work, we conducted a structure–activity relationship …
target for anti-cancer therapy. In this work, we conducted a structure–activity relationship …
Indazole as a privileged scaffold in drug discovery
S Cui - Privileged Scaffolds in Drug Discovery, 2023 - Elsevier
Indazole is a type of bicyclic heterocycle that has unique chemical and pharmacologic
properties and has been recognized as a privileged scaffold in drug discovery. In this …
properties and has been recognized as a privileged scaffold in drug discovery. In this …
A new era for cancer target therapies: Applying systems biology and computer-aided drug design to cancer therapies
YH Wong, CC Chiu, CL Lin, TS Chen… - Current …, 2016 - ingentaconnect.com
In recent years, many systems biology approaches have been used with various cancers.
The materials described here can be used to build bases to discover novel cancer therapy …
The materials described here can be used to build bases to discover novel cancer therapy …
A Simple Machine Learning-Based Quantitative Structure-Activity Relationship Model for Predicting pIC50 Inhibition Values of FLT3 Tyrosine Kinase
JJ Alcázar, I Sánchez, C Merino, B Monasterio… - 2024 - preprints.org
In this study, a simple machine learning-based quantitative structure-activity relationship
(QSAR) model was developed to predict the inhibitory potency (pIC50 values) of FLT3 …
(QSAR) model was developed to predict the inhibitory potency (pIC50 values) of FLT3 …
[PDF][PDF] Domain analysis and visualization of nlrp10
SH Tee - Int. J. Information Technol. Computer Sci, 2013 - Citeseer
NLRP10 is one of the members of NOD-like receptors (NLRs) family that is least
characterized. It is a protein that takes part in pathogen sensing and responsible for the …
characterized. It is a protein that takes part in pathogen sensing and responsible for the …