Organisms are continually exposed to exogenous and endogenous sources of reactive
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …

Circadian rhythms are internal manifestations of the solar day that permit adaptations to
predictable environmental temporal changes. These~ 24-h rhythms are controlled by …

Damage to specific brain circuits can cause specific neuropsychiatric symptoms.
Therapeutic stimulation to these same circuits may modulate these symptoms. To determine …

Short-chain fatty acids (SCFAs), the main metabolites produced by bacterial fermentation of
dietary fibre in the gastrointestinal tract, are speculated to have a key role in microbiota–gut …

Anxiety is experienced in response to threats that are distal or uncertain, involving changes
in one's subjective state, autonomic responses, and behavior. Defensive and physiologic …

The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …

Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA …

Psychopathy is a personality disorder characterized by a constellation of affective,
interpersonal, lifestyle and antisocial features whose antecedents can be identified in a …

Biomarkers have transformed modern medicine but remain largely elusive in psychiatry,
partly because there is a weak correspondence between diagnostic labels and their …

Anhedonia is considered a core feature of major depressive disorder, and the dopamine
system plays a pivotal role in the hedonic deficits described in this disorder. Dopaminergic …