Simple Summary Glioblastoma (GBM) is the most common form of primary malignant brain
tumor with a devastatingly poor prognosis. Tumor heterogeneity (cellular, molecular and …

Despite aggressive treatment regimens based on surgery and radiochemotherapy, the
prognosis of patients with grade IV glioblastoma multiforme (GBM) remains extremely poor …

Purpose: Adoptive T-cell immunotherapy (ACT) has emerged as a viable therapeutic for
peripheral and central nervous system (CNS) tumors. In peripheral cancers, optimal efficacy …

Nanomaterials are increasingly valued tools in drug delivery research as they offer
enhanced stability, controlled release and more effective drug encapsulation. Though yet to …

Злокачественные опухоли центральной нервной системы удерживают первое место по
среднегодовым темпам прироста заболеваемости в Российской Федерации …

Постоянный рост заболеваемости глиальными опухолями у взрослого населения и
неудовлетворительные результаты комбинированной терапии подталкивают к поиску …

Part I of this thesis aims at developing an extensible and computationally efficient framework
for in silico modeling of tumor growth in a 3-dimensional, inhomogeneous and time-varying …

Glioblastoma (GBM) is the most common form of primary malignant brain tumor with a
devastatingly poor prognosis. The disease does not discriminate, affecting adults and …

HGGs are aggressive brain tumors. With current standard therapies (surgery and chemo‐
radiation), the median survival of glioblastoma (GBM, the most malignant subtype of HGG) is …

Malignant gliomas are brain tumors derived from glial cells in the central nervous system.
Current therapies including surgical resection, chemotherapy, and radiation have yielded an …