G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved
in signal transmission, have recently emerged as crucial players in tumour growth and …

Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant,
commonly known as turmeric. Curcumin has been used extensively in Ayurvedic medicine …

Cancer stem cells (CSCs) play a critical role in invasive growth and metastasis of human
head and neck squamous cell carcinoma (HNSCC). Although significant progress has been …

The prognostication of head and neck squamous cell carcinoma (HNSCC) is largely based
upon the tumor size and location and the presence of lymph node metastases. Here we …

Members of the Fos family (c-Fos, FosB and its smaller splice variants, Fra-1 and Fra-2)
dimerise with Jun proteins to form the AP-1 transcription factor complex. Based on the …

Purpose High epidermal growth factor receptor (EGFR) gene copy number is associated
with poor prognosis in lung cancer, but such findings have not been reported for HNSCC. A …

Nuclear factor-κB (NF-κB) is a proinflammatory transcription factor that has emerged as an
important player in the development and progression of malignant cancers. NF-κB targets …

Nuclear factor kappa B (NF-κB) is a family of inducible transcription factors found virtually
ubiquitously in all cells. Since its discovery by Sen and Baltimore in 1986, much has been …

The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in
the field of cancer research from last few decades. Aberrant activation of this transcription …

Multiple genetic and epigenetic events, including the aberrant expression and function of
molecules regulating cell signaling, growth, survival, motility, angiogenesis, and cell cycle …