The health benefits of exercise are well-recognized and are observed across multiple organ
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …

Adiponectin is the most abundant peptide secreted by adipocytes, whose reduction plays a
central role in obesity-related diseases, including insulin resistance/type 2 diabetes and …

Background: Chronic diseases such as diabetes have an adverse effect on the quality of life
(QOL) of patients. It has been shown physical activity can improve the quality of life. Aims …

Increased dietary fiber consumption has been associated with many beneficial effects,
including amelioration of obesity and insulin resistance. These effects may be due to the …

Metabolism research has made tremendous progress over the last several decades in
establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Obesity-linked type 2 diabetes is one of the paramount causes of morbidity and mortality
worldwide, posing a major threat on human health, productivity, and quality of life. Despite …

Adipocytes are the main constituent of adipose tissue and are considered to be a corner
stone in the homeostatic control of whole body metabolism. Their primary function is to …

Objective Type 2 diabetes and obesity are pro-inflammatory states associated with
increased risk of cardiovascular disease. Canagliflozin, an SGLT2 inhibitor, demonstrated …

Adipose tissue dysfunction occurs with aging and has systemic effects, including peripheral
insulin resistance, ectopic lipid deposition, and inflammation. Fundamental aging …