Children and adolescents exhibit a broad range of clinical outcomes from SARS-CoV-2
infection, with the majority having minimal to mild symptoms. Additionally, some succumb to …

Vaccines based on historical virus isolates provide limited protection from continuously
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …

Annual epidemics of seasonal influenza cause hundreds of thousands of deaths, high levels
of morbidity, and substantial economic loss. Yet, global influenza circulation has been …

Importance Respiratory syncytial virus (RSV) mortality estimates have not been updated
since 2009, and no study has assessed changes in influenza mortality after the 2009 …

In addition to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), humans are
also susceptible to six other coronaviruses, for which consecutive exposures to antigenically …

Seasonal influenza viruses cause recurring global epidemics by continually evolving to
escape host immunity. The viral constraints and host immune responses that limit and drive …

There has been substantial research on adult COVID-19 and how to treat it. But how do
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections afflict children …

Pronounced immune escape by the SARS-CoV-2 Omicron variant has resulted in many
individuals possessing hybrid immunity, generated through a combination of vaccination …

Humans are repeatedly exposed to variants of influenza virus throughout their lifetime. As a
result, preexisting influenza-specific memory B cells can dominate the response after …

The spike glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
continues to accumulate substitutions, leading to breakthrough infections of vaccinated …