The interaction between ferroptosis and inflammatory signaling pathways

Y Chen, ZM Fang, X Yi, X Wei, DS Jiang - Cell Death & Disease, 2023 - nature.com
Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation.
Inflammation is one common and effective physiological event that protects against various …

NF‐κB signaling in inflammation and cancer

T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

A spotlight on the interplay of signaling pathways and the role of miRNAs in osteosarcoma pathogenesis and therapeutic resistance

AS Doghish, M Hegazy, A Ismail, HA El-Mahdy… - … -Research and Practice, 2023 - Elsevier
Osteosarcoma (OS) is one of the most common bone cancers that constantly affects
children, teenagers, and young adults. Numerous epigenetic elements, such as miRNAs …

TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Myeloid-derived suppressor cells: a propitious road to clinic

A Grover, E Sanseviero, E Timosenko, DI Gabrilovich - Cancer discovery, 2021 - AACR
Myeloid-derived suppressor cells (MDSC) are important regulators of immune responses in
cancer. They represent a relatively stable form of pathologic activation of neutrophils and …

Micro-algal astaxanthin improves lambda-cyhalothrin-induced necroptosis and inflammatory responses via the ROS-mediated NF-κB signaling in lymphocytes of carp …

J Cai, P Liu, X Zhang, B Shi, Y Jiang, S Qiao… - Fish & Shellfish …, 2023 - Elsevier
Lambda-cyhalothrin (LCY) is a widely used toxic pesticide that causes harmful effects on the
immune organs of fish and aquatic species. Micro-algal astaxanthin (MAA), a heme pigment …

Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes

S Nirenjen, J Narayanan, T Tamilanban… - Frontiers in …, 2023 - frontiersin.org
Background Impaired wound healing is the most common and significant complication of
Diabetes. While most other complications of Diabetes have better treatment options, diabetic …

Targeted therapy for head and neck cancer: signaling pathways and clinical studies

Q Li, Y Tie, A Alu, X Ma, H Shi - Signal Transduction and Targeted …, 2023 - nature.com
Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

[HTML][HTML] Advances in the development of therapeutic strategies against COVID-19 and perspectives in the drug design for emerging SARS-CoV-2 variants

J Yin, C Li, C Ye, Z Ruan, Y Liang, Y Li, J Wu… - Computational and …, 2022 - Elsevier
Abstract Since Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was
identified in late 2019, the coronavirus disease 2019 (COVID-19) pandemic has challenged …

Cellular senescence in intervertebral disc aging and degeneration: molecular mechanisms and potential therapeutic opportunities

P Silwal, AM Nguyen-Thai, HA Mohammad, Y Wang… - Biomolecules, 2023 - mdpi.com
Closely associated with aging and age-related disorders, cellular senescence (CS) is the
inability of cells to proliferate due to accumulated unrepaired cellular damage and …