The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involved

F Coperchini, L Chiovato, G Ricci, L Croce… - Cytokine & Growth …, 2021 - Elsevier
SARS-COV-2 infection represents the greatest pandemic of the world, counting daily
increasing number of subjects positive to the virus and, sadly, increasing number of deaths …

Innate receptor activation patterns involving TLR and NLR synergisms in COVID-19, ALI/ARDS and sepsis cytokine storms: a review and model making novel …

R Root-Bernstein - International journal of molecular sciences, 2021 - mdpi.com
Severe COVID-19 is characterized by a “cytokine storm”, the mechanism of which is not yet
understood. I propose that cytokine storms result from synergistic interactions among Toll …

SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages

GJ Martínez-Colón, K Ratnasiri, H Chen… - Science Translational …, 2022 - science.org
Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the …

The K18-human ACE2 transgenic mouse model recapitulates non-severe and severe COVID-19 in response to an infectious dose of the SARS-CoV-2 virus

W Dong, H Mead, L Tian, JG Park, JI Garcia… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT A comprehensive analysis and characterization of a severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe …

Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic

A Hasankhani, A Bahrami, N Sheybani, B Aria… - Frontiers in …, 2021 - frontiersin.org
Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …

[HTML][HTML] The association of airborne particulate matter and benzo [a] pyrene with the clinical course of COVID-19 in patients hospitalized in Poland

P Rzymski, B Poniedziałek, J Rosińska… - Environmental …, 2022 - Elsevier
Air pollution can adversely affect the immune response and increase the severity of the viral
disease. The present study aimed to explore the relationship between symptomatology …

ACE2-dependent and-independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection

T Duan, C Xing, J Chu, X Deng, Y Du, X Liu, Y Hu… - Nature Cell …, 2024 - nature.com
Excessive inflammation is the primary cause of mortality in patients with severe COVID-19,
yet the underlying mechanisms remain poorly understood. Our study reveals that ACE2 …

[HTML][HTML] Lung cancer and severe acute respiratory syndrome coronavirus 2 infection: identifying important knowledge gaps for investigation

C Rolfo, N Meshulami, A Russo, F Krammer… - Journal of Thoracic …, 2022 - Elsevier
Patients with lung cancer are especially vulnerable to coronavirus disease 2019 (COVID-19)
with a greater than sevenfold higher rate of becoming infected with severe acute respiratory …

[HTML][HTML] Revised guidelines for coronavirus disease 19 management in hematopoietic cell transplantation and cellular therapy recipients (August 2022)

V Dioverti, Z El Boghdadly, Z Shahid… - … and Cellular Therapy, 2022 - Elsevier
This document is intended as a guide for diagnosis and management of Coronavirus
Disease 2019 (COVID-19), caused by the virus SARS-CoV-2, in adult and pediatric HCT …

Lipopolysaccharide induces acute lung injury and alveolar haemorrhage in association with the cytokine storm, coagulopathy and AT1R/JAK/STAT augmentation in a …

B Al‐Ani, AM ShamsEldeen, SS Kamar… - Clinical and …, 2022 - Wiley Online Library
Progress in the study of Covid‐19 disease in rodents has been hampered by the lack of
angiotensin‐converting enzyme 2 (ACE2; virus entry route to the target cell) affinities for the …