Peroxisome proliferator-activated receptor gamma (PPARγ) has been implicated in the
pathology of numerous diseases involving diabetes, stroke, cancer, or obesity. It is …

Experimental treatment strategies and neuroprotective drugs that showed therapeutic
promise in animal models of stroke have failed to produce beneficial effects in human stroke …

Microglial activation plays a central role in poststroke inflammation and causes secondary
neuronal damage; however, it also contributes in debris clearance and chronic recovery …

Rodents are the most widely used experimental animals in stroke research due to their
similar vascular anatomy, high reproductive rates, and availability of transgenic models …

Ambivalent effects of interleukin-6 on the pathogenesis of ischaemic stroke have been
reported. However, to date, the long-term actions of interleukin-6 after stroke have not been …

Background Discoveries that microglia-mediated neuroinflammation is involved in the
pathological process of depression provided a new strategy for novel antidepressant …

Autophagy is an important homeostatic cellular process encompassing a number of
consecutive steps indispensable for degrading and recycling cytoplasmic materials …

After stroke, macrophages in the ischemic brain may be derived from either resident
microglia or infiltrating monocytes. Using bone marrow (BM)-chimerism and dual-reporter …

Neonatal hypoxic–ischemic encephalopathy (HIE) is increasingly recognized as a sexually
dimorphic disease. Male infants are not only more vulnerable to ischemic insult; they also …

Microglial activation is a key element in initiating and perpetuating inflammatory responses
to stroke. Interferon regulatory factor 5 (IRF 5) and IRF 4 signaling have been found critical in …