COVID-19 challenges: From SARS-CoV-2 infection to effective point-of-care diagnosis by electrochemical biosensing platforms

D Campos-Ferreira, V Visani, C Córdula… - Biochemical …, 2021 - Elsevier
Abstract In January 2020, the World Health Organization (WHO) identified a new zoonotic
virus, SARS-CoV-2, responsible for causing the COVID-19 (coronavirus disease 2019) …

Races of small molecule clinical trials for the treatment of COVID‐19: an up‐to‐date comprehensive review

S Hu, S Jiang, X Qi, R Bai, XY Ye… - Drug Development …, 2022 - Wiley Online Library
Abstract The coronavirus disease‐19 (COVID‐19) pandemic has become a global threat
since its first outbreak at the end of 2019. Several review articles have been published …

Characterization by quantitative serum proteomics of immune-related prognostic biomarkers for COVID-19 symptomatology

M Villar, JM Urra, FJ Rodríguez-del-Río… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 pandemic caused by SARS-CoV-2 challenges the understanding of factors
affecting disease progression and severity. The identification of prognostic biomarkers and …

Reductionist methodology and the ambiguity of the categories of race and ethnicity in biomedical research: an exploratory study of recent evidence

JK Malinowska, T Żuradzki - Medicine, Health Care and Philosophy, 2023 - Springer
In this article, we analyse how researchers use the categories of race and ethnicity with
reference to genetics and genomics. We show that there is still considerable conceptual …

The main post-translational modifications and related regulatory pathways in the malaria parasite Plasmodium falciparum: An update

S Rashidi, R Tuteja, R Mansouri… - Journal of …, 2021 - Elsevier
There are important challenges when investigating individual post-translational
modifications (PTMs) or protein interaction network and delineating if PTMs or their changes …

Identification of Disalicyloyl Curcumin as a Potential DNA Polymerase Inhibitor for Marek's Disease Herpesvirus: A Computational Study Using Virtual Screening and …

A Cherif, Z Basharat, M Yaseen, MA Bhat, I Uddin… - Molecules, 2023 - mdpi.com
Marek's disease virus (MDV) is a highly contagious and persistent virus that causes T-
lymphoma in chickens, posing a significant threat to the poultry industry despite the …

Uncovering the Effect of SARS-CoV-2 on Liver Metabolism via Genome-Scale Metabolic Modeling for Reprogramming and Therapeutic Strategies

M Sertbas, KO Ulgen - ACS omega, 2024 - ACS Publications
Genome-scale metabolic models (GEMs) are promising computational tools that contribute
to elucidating host–virus interactions at the system level and developing therapeutic …

Artificial intelligence assessment of the potential of tocilizumab along with corticosteroids therapy for the management of COVID-19 evoked acute respiratory distress …

C Segú-Vergés, L Artigas, M Coma, RW Peck - Plos one, 2023 - journals.plos.org
Acute respiratory distress syndrome (ARDS), associated with high mortality rate, affects up to
67% of hospitalized COVID-19 patients. Early evidence indicated that the pathogenesis of …

In silico investigation of the viroporin E as a vaccine target against SARS-CoV-2

E Rouka, KI Gourgoulianis… - American Journal of …, 2021 - journals.physiology.org
Viroporins, integral viral membrane ion channel proteins, interact with host-cell proteins
deregulating physiological processes and activating inflammasomes. Severity of COVID-19 …

Integrative In Silico Investigation Reveals the Host-Virus Interactions in Repurposed Drugs Against SARS-CoV-2

W Yu, Y Bai, A Raha, Z Su, F Geng - Frontiers in Bioinformatics, 2022 - frontiersin.org
The ongoing COVID-19 outbreak have posed a significant threat to public health worldwide.
Recently Toll-like receptor (TLR) has been proposed to be the drug target of SARS-CoV-2 …