Cardiac fibrosis is a common finding that is associated with the progression of heart failure
(HF) and impacts all chambers of the heart. Despite intense research, the treatment of HF …

The fate of leukaemia stem cells (LSCs) is determined by both their inherent mechanisms
and crosstalk with their niches. Although LSCs were confirmed to be eradicated by restarting …

Macroautophagy/autophagy is a conserved degradation system that engulfs
intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for …

Caloric restriction has been associated with increased life span and reduced aging-related
disorders and reduces fibrosis in several diseases. Fibrosis is characterized by deposition of …

The cholangiopathies are a group of liver diseases that affect cholangiocytes, the epithelial
cells that line the bile ducts. Biliary atresia (BA), primary biliary cholangitis (PBC), and …

Triple negative breast cancer (TNBC) is an aggressive subtype with relatively poor clinical
outcomes and limited treatment options. Chemotherapy, while killing cancer cells, can result …

Cellular senescence plays an important role in different biological and pathological
conditions. Senescent cells communicate with their microenvironment through a plethora of …

Senescent cells accumulate in several tissues during ageing and contribute to several
pathological processes such as ageing and cancer. Senescence induction is a complex …

Microtubule-associated protein Tau can form protein aggregates transmissible within the
brain, correlating with the progression of tauopathies in humans. The transmission of …

In recent years, cellular senescence has become the focus of attention in multiple areas of
biomedical research. Typically defined as an irreversible cell cycle arrest accompanied by …