The molecular hybridization of different compounds with known pharmacological activity is a
particularly prominent approach for the design of potential drugs with improved …

Different compounds have been investigated as potent drugs for trypanosomiasis treatment,
but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as …

Indazole is an important heterocyclic scaffold exhibiting a wide range of biological and
pharmacological properties and plays a crucial role in drug design. In recent years …

Oxidative stress is involved in several parasitic diseases such as Chagas. Agents able to
selectively modulate biochemical processes involved in the disease represent promising …

Chagas disease is a devastating neglected disease caused by the parasite Trypanosoma
cruzi, which affects millions of people worldwide. The two anti-parasitic drugs available …

Two series of new 5-nitroindazole derivatives, 1-substituted 2-benzylindazolin-3-ones (6–
29, series A) and 3-alkoxy-2-benzyl-2H-indazoles (30–37, series B), containing differently …

1H-Indazoles are important heterocycles as they are a substantial part in many drugs. Here,
a DBU-catalyzed aza-Michael reaction of indazole with enones is described. A variety of …

The synthesis and antiprotozoal activity of some 3-alkoxy-1-alkyl-(1, 4) and 3-alkoxy-1-(ω-
aminoalkyl)-5-nitroindazoles (2, 3, 5–8) against different morphological forms of …

Chagas disease is the most widespread contagious tropical disease in Latin America, being
an important public health problem. Treatments against this disease are still very ineffective …

Background: Neglected diseases are becoming more prevalent due to globalization. This
has inspired active research in the development of new drugs for the treatment of parasitic …