From a biological point of view, aging can be considered a progressive inability of an
organism to react to stress, maintain homeostasis, and survive unfavourable changes during …

Obesity is a metabolic disorder of increasing prevalence worldwide and a risk factor for the
development of insulin resistance (IR), metabolic syndrome and type 2 diabetes. Obesity is …

Visfatin has recently been identified as a novel visceral adipokine which may be involved in
obesity-related vascular disorders. However, it is not known whether visfatin directly …

Background—We tested the hypothesis that nuclear factor-κB (NF-κB) activity contributes to
vascular endothelial dysfunction with aging and obesity in humans. Methods and Results …

Obesity is an ever-increasing phenomenon, with 42% of Americans being considered obese
(BMI≥ 30) and 9.2% being considered morbidly obese (BMI≥ 40) as of 2016. With obesity …

Interest in the biology of white adipose tissue has increased dramatically since the discovery
of leptin in 1994. The identification of the product of the gene obese (ob) threw light on the …

Objective We investigated the effects of high-fat diet-induced obesity on vascular
proinflammatory factors and oxidative stress on endothelium-dependent relaxation of the …

The endothelium plays a vital role in maintaining circulatory homeostasis by the release of
relaxing and contracting factors. Any change in this balance may result in a process known …

The adipose tissue (AT) is an endocrine organ that produces adipocytokines (adipokines),
able to influence metabolic homeostasis. In the conventional classification, there are two …

During obesity, chronic inflammation of human white adipose tissue (WAT) is associated
with metabolic and vascular alterations. Endothelial cells from visceral WAT (VAT-ECs) …