Nanotechnology: a promising approach for delivery of neuroprotective drugs
Central nervous system (CNS) disorders especially neurodegenerative disorders are the
major challenge for public health and demand the great attention of researchers to protect …
major challenge for public health and demand the great attention of researchers to protect …
HMGB1: a common biomarker and potential target for TBI, neuroinflammation, epilepsy, and cognitive dysfunction
High mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein released by glia
and neurons upon inflammasome activation and activates receptor for advanced glycation …
and neurons upon inflammasome activation and activates receptor for advanced glycation …
Brain penetrating peptides and peptide–drug conjugates to overcome the blood–brain barrier and target CNS diseases
Nearly one in six people worldwide suffer from disorders of the central nervous system
(CNS). There is an urgent need for effective strategies to improve the success rates in CNS …
(CNS). There is an urgent need for effective strategies to improve the success rates in CNS …
Nanoemulsions for “nose-to-brain” drug delivery
The blood–brain barrier (BBB) plays a fundamental role in protecting the brain from toxic
substances and therefore also controls and restricts the entry of therapeutic agents. The …
substances and therefore also controls and restricts the entry of therapeutic agents. The …
The role of inflammation in epilepsy
Epilepsy is the third most common chronic brain disorder, and is characterized by an
enduring predisposition to generate seizures. Despite progress in pharmacological and …
enduring predisposition to generate seizures. Despite progress in pharmacological and …
The blood–brain barrier in health and disease
R Daneman - Annals of neurology, 2012 - Wiley Online Library
The blood–brain barrier (BBB) is a term used to describe a series of properties possessed
by the vasculature of the central nervous system (CNS) that tightly regulate the movement of …
by the vasculature of the central nervous system (CNS) that tightly regulate the movement of …
Time to test antibacterial therapy in Alzheimer's disease
Alzheimer's disease is associated with cerebral accumulation of amyloid-β peptide and
hyperphosphorylated tau. In the past 28 years, huge efforts have been made in attempting to …
hyperphosphorylated tau. In the past 28 years, huge efforts have been made in attempting to …
Signaling mechanisms regulating endothelial permeability
D Mehta, AB Malik - Physiological reviews, 2006 - journals.physiology.org
The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …
The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells
The blood-brain barrier (BBB) maintains brain homeostasis and limits the entry of toxins and
pathogens into the brain. Despite its importance, little is known about the molecular …
pathogens into the brain. Despite its importance, little is known about the molecular …
Strategy for effective brain drug delivery
Blood–brain barrier (BBB) together with enzymes restricts the entry of substances for
maintaining the internal milieu of the brain. Because of the presence of multiple endogenous …
maintaining the internal milieu of the brain. Because of the presence of multiple endogenous …