In the last 30 years, over 20 new anti-seizure medicines (ASMs) have been introduced into
the market for the treatment of epilepsy using well-established preclinical seizure and …

A large set of inflammatory molecules and their receptors are induced in epileptogenic foci
of patients with pharmacoresistant epilepsies of structural etiologies or with refractory status …

Epilepsy, one of the most severe neurological diseases, is characterized by abrupt recurrent
seizures. Despite great progress in the development of antiseizure drugs (ASDs) based on …

Ample evidence has suggested the stress etiology of depression, but the underlying
mechanism is not fully understood yet. Here, we report that chronic social defeat stress …

Epilepsy is not well controlled by current anti-seizure drugs (ASDs). High mobility group box
1 (HMGB1) is a DNA-binding protein in the nucleus regulating transcriptional activity and …

Status epilepticus (SE) is a medical emergency resulting from the failure of the mechanisms
involved in seizure termination or from the initiation of pathways involved in abnormally …

Secondary epileptogenesis is a common phenomenon in epilepsy, characterized by
epileptiform discharges from the regions outside the primary focus. It is one of the major …

Epilepsy, which is characterized by spontaneous recurrent seizures, is one of the most
common and serious chronic neurological diseases in the world. 30% patients failed to …

Progressive ischemic stroke (PIS) is featured by progressive neurological dysfunction after
ischemia. Ischemia-evoked neuroinflammation is implicated in the progressive brain injury …

The ATP1A3 gene which encodes the Na+/K+-ATPase α3 catalytic subunit plays a crucial
role in both physiological and pathological conditions in the brain, and mutations in this …