Chromatin structure imposes significant obstacles on all aspects of transcription that are
mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated …

Knowing the precise locations of nucleosomes in a genome is key to understanding how
genes are regulated. Recent'next generation'ChIP–chip and ChIP–Seq technologies have …

In eukaryotes, all DNA-templated reactions occur in the context of chromatin. Nucleosome
packaging inherently restricts DNA accessibility for regulatory proteins but also provides an …

Transcriptional activation of the interferon-β (IFN-β) gene requires assembly of an
enhanceosome containing ATF-2/c-Jun, IRF-3/IRF-7, and NFκB. These factors bind …

Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …

Krüppel-associated box domain-zinc finger proteins (KRAB–ZFPs) are tetrapod-specific
transcriptional repressors encoded in the hundreds by the human genome. In order to …

Complexes formed from the nuclear factor κB (NF-κB) family of transcription factors are
ubiquitously expressed and are induced by a diverse array of stimuli. This results in their …

We report the results of experiments designed to test the histone code hypothesis. We found
that only a small subset of lysines in histones H4 and H3 are acetylated in vivo by the GCN5 …

Rapid induction of type I interferon (IFN) expression is a central event in the establishment of
the innate immune response against viral infection and requires the activation of multiple …

Histone proteins play structural and functional roles in all nuclear processes. They undergo
different types of covalent modifications, defined in their ensemble as epigenetic because …