Associations between gut microbiota and Parkinson disease: a bidirectional Mendelian randomization analysis

L Jiang, J Li, B Tang, J Guo - European Journal of Neurology, 2023 - Wiley Online Library
Background and purpose Parkinson disease (PD)‐associated alterations in the gut
microbiome have been observed in clinical and animal studies. However, it remains unclear …

[HTML][HTML] Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside

YY Ma, X Li, JT Yu, YJ Wang - Translational Neurodegeneration, 2024 - Springer
The aetiologies and origins of neurodegenerative diseases, such as Alzheimer's disease
(AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's …

The critical role of gut-brain axis microbiome in mental disorders

K Basiji, AA Sendani, SB Ghavami, M Farmani… - Metabolic brain …, 2023 - Springer
The Gut-brain axis is a bidirectional neural and humoral signaling that plays an important
role in mental disorders and intestinal health and connects them as well. Over the past …

[HTML][HTML] Tributyrin alleviates gut microbiota dysbiosis to repair intestinal damage in antibiotic-treated mice

N Yang, T Lan, Y Han, H Zhao, C Wang, Z Xu, Z Chen… - PLoS …, 2023 - journals.plos.org
Tributyrin (TB) is a butyric acid precursor and has a key role in anti-inflammatory and
intestinal barrier repair effects by slowly releasing butyric acid. However, its roles in gut …

[HTML][HTML] Intestinal permeability, Dysbiosis, inflammation and enteric glia cells: the intestinal etiology of Parkinson's disease

H Yang, S Li, W Le - Aging and disease, 2022 - ncbi.nlm.nih.gov
The scientific and medical communities are becoming more aware of the substantial
relationship between the function of the central nervous system (CNS) and the state of the …

Comprehensive review on potential signaling pathways involving the transfer of α-synuclein from the gut to the brain that leads to Parkinson's disease

S Kumari, R Taliyan, SK Dubey - ACS Chemical Neuroscience, 2023 - ACS Publications
Parkinson's disease is the second most prevalent neurological disease after Alzheimer's.
Primarily, old age males are more affected than females. The aggregates of oligomeric forms …

[HTML][HTML] Small intestinal bacterial overgrowth as potential therapeutic target in Parkinson's disease

A Dănău, L Dumitrescu, A Lefter, D Tulbă… - International journal of …, 2021 - mdpi.com
Increasing evidence suggests that the gut microbiota and the brain are closely connected
via the so-called gut–brain axis. Small intestinal bacterial overgrowth (SIBO) is a gut …

Ketone body β-hydroxybutyric acid ameliorates dopaminergic neuron injury through modulating zinc finger protein 36/Acyl-CoA synthetase long-chain family member …

X Yu, Y Yang, B Zhang, G Han, J Yu, Q Yu, L Zhang - Neuroscience, 2023 - Elsevier
Abstract β-hydroxybutyrate (BHB) is one of main component of ketone body, which plays an
important protective role in various tissues and organs. Whereas, its exact regulatory roles …

[HTML][HTML] Microbiome–gut–brain dysfunction in prodromal and symptomatic Lewy body diseases

S Ryman, AA Vakhtin, SP Richardson, HC Lin - Journal of neurology, 2023 - Springer
Lewy body diseases, such as Parkinson's disease and dementia with Lewy bodies, vary in
their clinical phenotype but exhibit the same defining pathological feature, α-synuclein …

[HTML][HTML] Bacterial translocation in gastrointestinal cancers and cancer treatment

K Kouzu, H Tsujimoto, Y Kishi, H Ueno, N Shinomiya - Biomedicines, 2022 - mdpi.com
In recent years, there has been increasing evidence that gut microbiota is associated with
the onset and exacerbation of various diseases, such as gastrointestinal cancer. For …