MicroRNA-34a: the bad guy in age-related vascular diseases

A Raucci, F Macrì, S Castiglione, I Badi… - Cellular and Molecular …, 2021 - Springer
The age-related vasculature alteration is the prominent risk factor for vascular diseases
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …

Lipoprotein (a): Knowns, unknowns and uncertainties

M Ruscica, CR Sirtori, A Corsini, GF Watts… - Pharmacological …, 2021 - Elsevier
Over the last 10 years, there have been advances on several aspects of lipoprotein (a)
which are reviewed in the present article. Since the standard immunoassays for measuring …

Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects

WQ Ma, XJ Sun, Y Zhu, NF Liu - Free Radical Biology and Medicine, 2021 - Elsevier
Ferroptosis is a form of regulated cell death that involves metabolic dysfunction resulting
from iron-dependent excessive lipid peroxidation. Elevated plasma levels of free fatty acids …

SGLT2-inhibitors are effective and safe in the elderly: The SOLD study

ME Lunati, V Cimino, A Gandolfi, M Trevisan… - Pharmacological …, 2022 - Elsevier
Background and aims Sodium-glucose co-transporter-2 inhibitors (SGLT2i) may have
important benefits for the elderly with type 2 diabetes (T2D), however some safety concerns …

Oleoylethanolamide alleviates hyperlipidaemia-mediated vascular calcification via attenuating mitochondrial DNA stress triggered autophagy-dependent ferroptosis …

Z Chen, X Sun, X Li, N Liu - Biochemical Pharmacology, 2023 - Elsevier
Vascular calcification, a prevalent pathological alteration in metabolic syndromes, is tightly
related with cardiometabolic risk events. Ferroptosis, a newly iron-dependent programmed …

Matrix vesicles as a therapeutic target for vascular calcification

T Li, H Yu, D Zhang, T Feng, M Miao, J Li… - Frontiers in Cell and …, 2022 - frontiersin.org
Vascular calcification (VC) is linked to an increased risk of heart disease, stroke, and
atherosclerotic plaque rupture. It is a cell-active process regulated by vascular cells rather …

Biomimetic grapefruit-derived extracellular vesicles for safe and targeted delivery of sodium thiosulfate against vascular calcification

W Feng, Y Teng, Q Zhong, Y Zhang, J Zhang, P Zhao… - ACS …, 2023 - ACS Publications
As the prevalence of vascular calcification (VC), a strong contributor to cardiovascular
morbidity and mortality, continues to increase, the need for pharmacologic therapies …

Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway

W Mao, Y Fan, X Wang, G Feng, Y You, H Li… - Pharmacological …, 2022 - Elsevier
Diabetic cardiovascular complications contribute more than half of diabetes mortality.
Endothelial damage and subsequent pathological changes play a key role in this process …

[HTML][HTML] Dietary antioxidants and vascular calcification: From pharmacological mechanisms to challenges

Y Lian, Y Li, A Liu, S Ghosh, Y Shi, H Huang - Biomedicine & …, 2023 - Elsevier
Vascular calcification (VC), an actively regulated process, has been recognized as an
independent and strong predictor of cardiovascular disease (CVD) and mortality worldwide …

Apoptosis in the extraosseous calcification process

F Boraldi, FD Lofaro, D Quaglino - Cells, 2021 - mdpi.com
Extraosseous calcification is a pathologic mineralization process occurring in soft connective
tissues (eg, skin, vessels, tendons, and cartilage). It can take place on a genetic basis or as …