Atypical antipsychotics (AAPs) are commonly prescribed medications to treat schizophrenia,
bipolar disorders and other psychotic disorders. However, they might cause metabolic …

Cyclobutanes are increasingly used in medicinal chemistry in the search for relevant
biological properties. Important characteristics of the cyclobutane ring include its unique …

Elevated dopamine transmission in psychosis is assumed to unbalance striatal output
through D1-and D2-receptor-expressing spiny-projection neurons (SPNs). Antipsychotic …

Dopamine (DA) is a major monoamine neurotransmitter in the brain and has essential roles
in higher functions of the brain. Malfunctions of dopaminergic signaling have been …

Psychedelics, also known as classical hallucinogens, have been investigated for decades
due to their potential therapeutic effects in the treatment of neuropsychiatric and substance …

Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …

Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its
genetic and environmental causes has considerably improved, and their relationship to …

Schizophrenia is a chronic and debilitating neuropsychiatric disorder affecting
approximately 1% of the world's population. This disease is associated with considerable …

The introduction of atypical antipsychotics (AAPs) since the discovery of its prototypical drug
clozapine has been a revolutionary pharmacological step for treating psychotic patients as …

Atypical antipsychotic drugs (APDs) have been hypothesized to show reduced
extrapyramidal side effects (EPS) due to their rapid dissociation from the dopamine D2 …