The landscape of mRNA nanomedicine

X Huang, N Kong, X Zhang, Y Cao, R Langer, W Tao - Nature Medicine, 2022 - nature.com
Messenger RNA (mRNA) is an emerging class of therapeutic agent for the prevention and
treatment of a wide range of diseases. The recent success of the two highly efficacious …

mRNA-based cancer therapeutics

C Liu, Q Shi, X Huang, S Koo, N Kong, W Tao - Nature Reviews Cancer, 2023 - nature.com
Due to the fact that mRNA technology allows the production of diverse vaccines and
treatments in a shorter time frame and with reduced expense compared to conventional …

Cancer nanomedicine toward clinical translation: Obstacles, opportunities, and future prospects

P Zhang, Y Xiao, X Sun, X Lin, S Koo, AV Yaremenko… - Med, 2023 - cell.com
With the integration of nanotechnology into the medical field at large, great strides have
been made in the development of nanomedicines for tackling different diseases, including …

Stimuli-responsive gene delivery nanocarriers for cancer therapy

Q Zhang, G Kuang, W Li, J Wang, H Ren, Y Zhao - Nano-Micro Letters, 2023 - Springer
Gene therapy provides a promising approach in treating cancers with high efficacy and
selectivity and few adverse effects. Currently, the development of functional vectors with …

Glioma diagnosis and therapy: current challenges and nanomaterial-based solutions

T Li, J Li, Z Chen, S Zhang, S Li, S Wageh… - Journal of controlled …, 2022 - Elsevier
Glioma is often referred to as one of the most dreadful central nervous system (CNS)-specific
tumors with rapidly-proliferating cancerous glial cells, accounting for nearly half of the brain …

Chemically modified platforms for better RNA therapeutics

Y Shi, X Zhen, Y Zhang, Y Li, S Koo, Q Saiding… - Chemical …, 2024 - ACS Publications
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …

Marine‐Derived Hydrogels for Biomedical Applications

X Lin, J Wang, X Wu, Y Luo, Y Wang… - Advanced Functional …, 2023 - Wiley Online Library
Marine organisms provide novel and broad sources for the preparations and applications of
biomaterials. Since the urgent requirement of bio‐hydrogels to mimic tissue extracellular …

Urchin-like ceria nanoparticles for enhanced gene therapy of osteoarthritis

H Chen, T Ye, F Hu, K Chen, B Li, M Qiu, Z Chen… - Science …, 2023 - science.org
Osteoarthritis (OA) is the most common degenerative joint disease in the world. Gene
therapy based on delivering microRNAs (miRNAs) into cells has potential for the treatment …

Recent advances in chitosan and its derivatives in cancer treatment

J Ding, Y Guo - Frontiers in Pharmacology, 2022 - frontiersin.org
Cancer has become a main public health issue globally. The conventional treatment
measures for cancer include surgery, radiotherapy and chemotherapy. Among the various …

Manipulating offense and defense signaling to fight cold tumors with carrier‐free nanoassembly of fluorinated prodrug and siRNA

P Wu, H Zhang, M Sun, S Mao, Q He, Y Shi… - Advanced …, 2022 - Wiley Online Library
Chemoimmunotherapy has shown great potential to activate an immune response, but the
immunosuppressive microenvironment associated with T cell exhaustion remains a …