The potential intermediate hosts for SARS-CoV-2

J Zhao, W Cui, B Tian - Frontiers in microbiology, 2020 - frontiersin.org
The coronavirus disease 19 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has become a global pandemic since the first report in …

Effective inhibition of MERS-CoV infection by resveratrol

SC Lin, CT Ho, WH Chuo, S Li, TT Wang… - BMC infectious diseases, 2017 - Springer
Abstract Background Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an
emerging viral pathogen that causes severe morbidity and mortality. Up to date, there is no …

Coronavirus spike protein and tropism changes

RJG Hulswit, CAM De Haan, BJ Bosch - Advances in virus research, 2016 - Elsevier
Coronaviruses (CoVs) have a remarkable potential to change tropism. This is particularly
illustrated over the last 15 years by the emergence of two zoonotic CoVs, the severe acute …

Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4

K Li, C Wohlford-Lenane, S Perlman… - The Journal of …, 2016 - academic.oup.com
Middle East respiratory syndrome coronavirus (MERS-CoV) causes life-threatening disease.
Dipeptidyl peptidase 4 (DPP4) is the receptor for cell binding and entry. There is a need for …

Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture

AH De Wilde, D Jochmans, CC Posthuma… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Coronaviruses can cause respiratory and enteric disease in a wide variety of human and
animal hosts. The 2003 outbreak of severe acute respiratory syndrome (SARS) first …

MERS-CoV: understanding the latest human coronavirus threat

A Chafekar, BC Fielding - Viruses, 2018 - mdpi.com
Human coronaviruses cause both upper and lower respiratory tract infections in humans. In
2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe …

MERS-CoV spike protein: a key target for antivirals

L Du, Y Yang, Y Zhou, L Lu, F Li… - Expert opinion on …, 2017 - Taylor & Francis
ABSTRACT Introduction: The continual Middle East respiratory syndrome (MERS) threat
highlights the importance of developing effective antiviral therapeutics to prevent and treat …

SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4

F Onodi, L Bonnet-Madin, L Meertens, L Karpf… - Journal of Experimental …, 2021 - rupress.org
Several studies have analyzed antiviral immune pathways in late-stage severe COVID-19.
However, the initial steps of SARS-CoV-2 antiviral immunity are poorly understood. Here we …

Broad-spectrum coronavirus antiviral drug discovery

AL Totura, S Bavari - Expert opinion on drug discovery, 2019 - Taylor & Francis
Introduction: The highly pathogenic coronaviruses severe acute respiratory syndrome
coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) …

COVID‐19 and comorbidities: A role for dipeptidyl peptidase 4 (DPP4) in disease severity?

MF Bassendine, SH Bridge, GW McCaughan… - Journal of …, 2020 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic is caused by a novel
betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), similar …