Middle East respiratory syndrome virus pathogenesis

SK Singh - Seminars in respiratory and critical care medicine, 2016 - thieme-connect.com
Coronaviruses (CoVs) are enveloped RNA viruses that infect birds, mammals, and humans.
Infections caused by human coronaviruses (hCoVs) are mostly associated with the …

Perspectives of antidiabetic drugs in diabetes with coronavirus infections

B Sun, S Huang, J Zhou - Frontiers in Pharmacology, 2021 - frontiersin.org
Diabetes mellitus (DM) increases the risk of viral infections especially during the period of
poor glycemic controls. Emerging evidence has reported that DM is one of the most common …

Middle East Respiratory Syndrome (MERS) virus—pathophysiological axis and the current treatment strategies

AM Alnuqaydan, AG Almutary, A Sukamaran… - AAPS …, 2021 - Springer
Middle East respiratory syndrome (MERS) is a lethal respiratory disease with its first case
reported back in 2012 (Jeddah, Saudi Arabia). It is a novel, single-stranded, positive-sense …

Possible role of adenosine in COVID-19 pathogenesis and therapeutic opportunities

JD Geiger, N Khan, M Murugan… - Frontiers in pharmacology, 2020 - frontiersin.org
The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by Severe Acute
Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) requires urgent clinical interventions …

Therapeutic perspectives of CD26 inhibitors in imune-mediated diseases

X Hu, X Wang, X Xue - Molecules, 2022 - mdpi.com
The enzymatic activity of CD26/DPP4 (dipeptidyl peptidase 4/DPP4) is highlighted in
multiple studies to play a vital role in glucose metabolism by cleaving and inactivating the …

Middle East respiratory syndrome coronavirus: transmission and phylogenetic evolution

JA Al-Tawfiq, ZA Memish - Trends in microbiology, 2014 - cell.com
The Middle East respiratory syndrome coronavirus (MERS-CoV) was first described in 2012
and, subsequently, many cases were reported with a lower case fatality rate than initial …

Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19

NM Kirk, Y Liang, H Ly - Virulence, 2024 - Taylor & Francis
Animal models that can replicate clinical and pathologic features of severe human
coronavirus infections have been instrumental in the development of novel vaccines and …

Energetics based modeling of hydroxychloroquine and azithromycin binding to the SARS-CoV-2 spike (S) protein-ACE2 complex

S Sandeep, K McGregor - 2020 - chemrxiv.org
The use of hydroxychloroquine to aid in the disruption of the SARS-CoV-2 virus and to cure
or at least treat the COVID-19 disease is recently being reviewed in various clinical trials …

Identification of novel inhibitors of angiotensin-converting enzyme 2 (ACE-2) receptor from Urtica dioica to combat coronavirus disease 2019 (COVID-19)

S Upreti, JS Prusty, SC Pandey, A Kumar, M Samant - Molecular Diversity, 2021 - Springer
The pandemic outbreak of coronavirus (SARS-CoV-2) is rapidly spreading across the globe,
so the development of anti-SARS-CoV-2 agents is urgently needed. Angiotensin-converting …

Animal models for studying coronavirus infections and developing antiviral agents and vaccines

Q Lin, C Lu, Y Hong, R Li, J Chen, W Chen, J Chen - Antiviral Research, 2022 - Elsevier
In addition to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East
respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly …