Evolution has traditionally been a historical and descriptive science, and predicting future
evolutionary processes has long been considered impossible. However, evolutionary …

Although the ecological dynamics of the infant gut microbiome have been intensely studied,
relatively little is known about evolutionary dynamics in the infant gut microbiome. Here we …

Infusion of broadly neutralizing antibodies (bNAbs) has shown promise as an alternative to
anti-retroviral therapy against HIV. A key challenge is to suppress viral escape, which is …

Triple-drug therapies have transformed HIV from a fatal condition to a chronic one. These
therapies should prevent HIV drug resistance evolution, because one or more drugs …

The ability to accurately identify and quantify genetic signatures associated with soft
selective sweeps based on patterns of nucleotide variation has remained controversial. We …

Despite decades of research, identifying selective sweeps, the genomic footprints of positive
selection, remains a core problem in population genetics. Of the myriad methods that have …

Successful infectious disease interventions can result in large reductions in parasite
prevalence. Such demographic change has fitness implications for individual parasites and …

HIV's exceptionally high recombination rate drives its intrahost diversification, enabling
immune escape and multidrug resistance within people living with HIV. While we know that …

Intra-host dynamics are a core component of virus evolution but most intra-host data come
from a narrow range of hosts or experimental infections. Gaining broader information on the …

Inferring selective sweeps from genetic data has been a breakthrough in population
genetics. The most prominent examples come from populations suddenly exposed to …