Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …

The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …

Answer questions and earn CME/CNE Cancer and heart disease are the leading causes of
morbidity and mortality in the industrialized world. Modern treatment strategies have led to …

MATERIALS AND METHODS Surgical preparation. The experimental animals were handled
in compliance with the Guiding Principles in the Use and Care of Animals published by the …

Purpose Treatment of breast cancer with trastuzumab is complicated by cardiotoxicity in up
to 34% of the patients. In most patients, trastuzumab-induced cardiotoxicity (TIC) is …

Myocardial ischemia reperfusion injury contributes to adverse cardiovascular outcomes after
myocardial ischemia, cardiac surgery or circulatory arrest. Primarily, no blood flow to the …

Myocardial ischemia-reperfusion injury is an important cause of impaired heart function in
the early postoperative period subsequent to cardiac surgery. Reactive oxygen species …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Heart diseases due to myocardial ischemia, such as myocardial infarction or ischemic heart
failure, are major causes of death in developed countries, and their number is unfortunately …

Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …