All data pertinent to this PhD thesis is stored securely by the 50% funding partner of this
PhD, The Pirbright Institute. Data is available on request by contacting the Immunogenetics …

Human natural killer (NK) cells are essential for controlling infection, cancer and fetal
development. NK cell functions are modulated by interactions between polymorphic …

Natural killer (NK) cells play a crucial role in the control of viral infections and transformed,
cancerous cells. These innate cells have high cytotoxic capacities and use a multitude of …

摘要背景: 传统的HLA 测序分型技术都是对父系母系双倍体进行扩增, 由于HLA 多样性高,
产生了大量的模棱两可难题, 而采用基于组特异性单倍体全长测序分型方法来解决模棱两可结果 …

Acute myeloid leukemia (AML) is one of the most prevalent leukemia in adults. Among the
various NK receptors, killer immunoglobulin-like receptors (KIRs) carry out indispensable …

HLA-Bw4+ genotype randomized to the non-immunotherapy regimen. Conversely, patients
that did not have the KIR3DL1+/HLA-Bw4+ genotype showed no evidence of a difference in …

This thesis focuses on clinical manifestations and genetic risk factors in a cohort of
individuals with Behçet's Disease (BD) from the United Kingdom (UK). Chapter 1 outlines …

A persisting fetal microchimerism (FM+) in the maternal peripheral blood is associated with a
significantly increased survival of up to 42% of children after haploidentical hematopoietic …