Many of the motor symptoms of Parkinson disease (PD) can be preceded, sometimes for
several years, by non-motor symptoms that include hyposmia, sleep disorders, depression …

Converging evidence from genetic, pathological and experimental studies have increasingly
suggested an important role for autophagy impairment in Parkinson's Disease (PD). Genetic …

Parkinson's disease (PD) is the most prevalent central nervous system (CNS) movement
disorder and the second most common neurodegenerative disease overall. PD is …

A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

Mutations of the glucocerebrosidase (GBA) gene are the most important risk factor yet
discovered for Parkinson disease (PD). Homozygous GBA mutations result in Gaucher …

The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are
predominantly expressed in the brain. Whereas the A2AR has been implicated in normal …

Many agents developed for neuroprotective treatment of Parkinson disease (PD) have
shown great promise in the laboratory, but none have translated to positive results in …

Following the discovery of a higher than expected incidence of Parkinson Disease (PD) in
Gaucher disease, a lysosomal storage disorder, mutations in the glucocerebrocidase (GBA) …

Microglia-mediated neuroinflammation has been described as a common hallmark of
Parkinson's disease (PD) and is believed to further exacerbate the progressive …

Wingless-type mouse mammary tumor virus (MMTV) integration site (Wnt) signaling is one of
the most critical pathways in developing and adult tissues. In the brain, Wnt signaling …