Targeting galectin-3 in inflammatory and fibrotic diseases

S Bouffette, I Botez, F De Ceuninck - Trends in Pharmacological Sciences, 2023 - cell.com
Abstract Galectin (Gal)-3 is a β-galactoside-binding lectin emerging as a key player in
cardiac, hepatic, renal, and pulmonary fibrosis and inflammation, respiratory infections …

Development of galectin-3 targeting drugs for therapeutic applications in various diseases

R Ahmed, K Anam, H Ahmed - International Journal of Molecular …, 2023 - mdpi.com
Galectin-3 (Gal3) is one of the most studied members of the galectin family that mediate
various biological processes such as growth regulation, immune function, cancer …

The Pivotal Role of Galectin-3 in Viral Infection: A Multifaceted Player in Host–Pathogen Interactions

BS Stojanovic, B Stojanovic, J Milovanovic… - International Journal of …, 2023 - mdpi.com
Galectin-3 (Gal-3), a beta-galactoside-binding lectin, plays a pivotal role in various cellular
processes, including immune responses, inflammation, and cancer progression. This …

Cardiac biomarkers and their role in identifying increased risk of cardiovascular complications in COVID-19 patients

N Yaluri, A Stančáková Yaluri, P Žeňuch, Z Žeňuchová… - Diagnostics, 2023 - mdpi.com
Cardiovascular disease (CVD) is a global health concern, causing significant morbidity and
mortality. Both lifestyle and genetics influence the development of CVD. It is often diagnosed …

Can Galectin-3 be a reliable predictive biomarker for post-COVID syndrome development?

A Portacci, M Amendolara, VN Quaranta, I Iorillo… - Respiratory …, 2024 - Elsevier
Background and objectives Reliable biomarkers able to predict post-COVID syndrome
development are still lacking. The aim of the study was to evaluate the relationship between …

Galectin-3 as a Marker for Increased Thrombogenicity in COVID-19

M Puccini, K Jakobs, L Reinshagen, J Friebel… - International Journal of …, 2023 - mdpi.com
Galectin-3 is a beta-galactoside-binding lectin involved in inflammation and lung fibrosis
and postulated to enhance thrombosis. In COVID-19, it is considered to be a prognostic …

Increased levels of galectin-3 in critical COVID-19

I Nikitopoulou, AG Vassiliou, N Athanasiou… - International Journal of …, 2023 - mdpi.com
Severe COVID-19 is related to hyperinflammation and multiple organ injury, including
respiratory failure, thus requiring intensive care unit (ICU) admission. Galectin-3, a …

A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface

F Zhao, AC Tallarek, Y Wang, Y Xie, A Diemert… - Frontiers in …, 2023 - frontiersin.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic imposed a
risk of infection and disease in pregnant women and neonates. Successful pregnancy …

Serum Mac-2 binding protein glycosylation isomer and galectin-3 levels in adult-onset Still's disease and their association with cytokines

S Yoshida, T Koga, Y Fujita, H Yatsuhashi… - Frontiers in …, 2024 - frontiersin.org
Background Autoinflammation with cytokine dysregulation may be implicated in the
pathophysiology of adult-onset Still's disease (AOSD); however, the relationship between …

[HTML][HTML] Targeting Myeloid Differentiation Primary Response Protein 88 (MyD88) and Galectin-3 to Develop Broad-Spectrum Host-Mediated Therapeutics against …

KU Saikh, K Anam, H Sultana, R Ahmed… - International Journal of …, 2024 - mdpi.com
Nearly six million people worldwide have died from the coronavirus disease (COVID-19)
outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …