The interplay of dopamine metabolism abnormalities and mitochondrial defects in the pathogenesis of schizophrenia

H Xu, F Yang - Translational psychiatry, 2022 - nature.com
Dopamine (DA) is a major monoamine neurotransmitter in the brain and has essential roles
in higher functions of the brain. Malfunctions of dopaminergic signaling have been …

Oxidative stress and inflammation in first-episode psychosis: a systematic review and meta-analysis

D Fraguas, CM Díaz-Caneja, M Ayora… - Schizophrenia …, 2019 - academic.oup.com
Despite mixed findings, increasing evidence suggests that people with first-episode
psychosis (FEP) show increased pro-inflammatory and pro-oxidative status. We used the …

New atypical antipsychotics in the treatment of schizophrenia and depression

J Orzelska-Górka, J Mikulska, A Wiszniewska… - International journal of …, 2022 - mdpi.com
Schizophrenia and depression are heterogeneous disorders. The complex
pathomechanism of the diseases imply that medication responses vary across patients …

Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms

N Cattane, R Rossi, M Lanfredi, A Cattaneo - BMC psychiatry, 2017 - Springer
Background According to several studies, the onset of the Borderline Personality Disorder
(BPD) depends on the combination between genetic and environmental factors (GxE), in …

Structural brain changes in schizophrenia at different stages of the illness: a selective review of longitudinal magnetic resonance imaging studies

B Dietsche, T Kircher… - Australian & New Zealand …, 2017 - journals.sagepub.com
Objective: Schizophrenia is a devastating mental disorder accompanied by aberrant
structural brain connectivity. The question whether schizophrenia is a progressive brain …

EEG-based measures in at-risk mental state and early stages of schizophrenia: a systematic review

A Perrottelli, GM Giordano, F Brando, L Giuliani… - Frontiers in …, 2021 - frontiersin.org
Introduction: Electrophysiological (EEG) abnormalities in subjects with schizophrenia have
been largely reported. In the last decades, research has shifted to the identification of …

Neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio in non-affective psychosis: a meta-analysis and systematic review

MG Mazza, S Lucchi, A Rossetti… - The World Journal of …, 2020 - Taylor & Francis
Objectives: Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and
monocyte/lymphocyte ratio (MLR) are inexpensive and reproducible biomarkers of …

[HTML][HTML] Neurobiology of schizophrenia: a comprehensive review

E Luvsannyam, MS Jain, MKL Pormento, H Siddiqui… - Cureus, 2022 - ncbi.nlm.nih.gov
Schizophrenia is a debilitating disease that presents with both positive and negative
symptoms affecting cognition and emotions. Extensive studies have analyzed the different …

Finding the elusive psychiatric “lesion” with 21st-century neuroanatomy: a note of caution

DR Weinberger, E Radulescu - American Journal of …, 2016 - Am Psychiatric Assoc
The widespread use of MRI has led to a wealth of structural and functional anatomical
findings in patients with diverse psychiatric disorders that may represent insights into …

Prenatal exposure to environmental insults and enhanced risk of developing Schizophrenia and Autism Spectrum Disorder: focus on biological pathways and …

N Cattane, J Richetto, A Cattaneo - Neuroscience & Biobehavioral …, 2020 - Elsevier
When considering neurodevelopmental disorders (NDDs), Schizophrenia (SZ) and Autism
Spectrum Disorder (ASD) are considered to be among the most severe in term of …