Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …

Red blood cells (RBCs) units are the most requested transfusion product worldwide.
Indications for transfusion include symptomatic anaemia, acute sickle cell crisis, and acute …

Red blood cell (RBC) storage in the blood bank promotes the progressive accumulation of
metabolic alterations that may ultimately impact the erythrocyte capacity to cope with oxidant …

Rationale The implementation of mass spectrometry (MS)‐based metabolomics is
advancing many areas of biomedical research. The time associated with traditional …

Abstract Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) plays a key regulatory
function in glucose oxidation by mediating fluxes through glycolysis or the pentose …

Transfusion of red blood cells (RBCs) is one of the most valuable and widespread
treatments in modern medicine. Lifesaving RBC transfusions are facilitated by the cold …

Hypoxanthine catabolism in vivo is potentially dangerous as it fuels production of urate and,
most importantly, hydrogen peroxide. However, it is unclear whether accumulation of …

Blood storage promotes the rapid depletion of red blood cell (RBC) high-energy adenosine
triphosphate (ATP) and 2, 3-diphosphoglycerate (DPG), which are critical regulators of …

Metabolomic investigations of packed red blood cells (RBCs) stored under refrigerated
conditions in saline adenine glucose mannitol (SAGM) additives have revealed the …

Storage of packed red blood cells (RBCs) is associated with progressive accumulation of
lesions, mostly triggered by energy and oxidative stresses, which potentially compromise the …