Integrins are activatable molecules that are involved in adhesion and signalling. Of the 24
known human integrins, 3 are currently targeted therapeutically by monoclonal antibodies …

Local and systemic haemorrhage are common consequences of crotaline and viperine
envenoming. Several studies carried out using purified toxins have indicated that local …

The ability of fibronectin to bind cells can be accounted for by the tetrapeptide L-arginyl-
glycyl-L-aspartyl-L-serine, a sequence which is part of the cell attachment domain of …

The Arg-Gly-Asp sequence resides in the cell attachment region of fibronectin. Arg-Gly-Asp-
containing peptides support fibroblast attachment, inhibit fibroblast adhesion to fibronectin …

Fibrinogen (Fbg) mediates platelet aggregation by its interaction with the platelet
glycoprotein IIb-IIIa (integrin alpha IIb beta 3). Peptides containing the amino acid sequence …

A 49-residue protein, echistatin, which inhibits platelet aggregation, was purified from the
venom of the saw-scaled viper Echis carinatus. The purification procedure included gel …

Enclothelial cells and activated platelets express integrin-type receptors responsible for
adhesion to fibrinogen. We have located distinct integrin-directed endothelial cell and …

Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function
relationship of peptides corresponding Page 1 Biochemistry 1984, 23, 1767-1774 1767 …

We demonstrate that unstimulated platelets attach to immobilized fibrinogen in a selective
process mediated by the membrane glycoprotein (GP) complex IIb-IIIa (alpha IIb beta 3). The …

Four plasma proteins have been shown to be able to mediate platelet adhesion to synthetic
materials when they are adsorbed as purified proteins: fibrinogen (Fg), fibronectin (Fn) …