Mechanisms of peritoneal fibrosis: focus on immune cells–peritoneal stroma interactions

M Terri, F Trionfetti, C Montaldo, M Cordani… - Frontiers in …, 2021 - frontiersin.org
Peritoneal fibrosis is characterized by abnormal production of extracellular matrix proteins
leading to progressive thickening of the submesothelial compact zone of the peritoneal …

Molecular pathways in peritoneal fibrosis

MS Balzer - Cellular signalling, 2020 - Elsevier
Peritoneal dialysis (PD) is a renal replacement therapy for patients with end-stage renal
disease that is equivalent to hemodialysis with respect to adequacy, mortality, and other …

Fibrosis of peritoneal membrane as target of new therapies in peritoneal dialysis

V Masola, M Bonomini, S Borrelli, L Di Liberato… - International journal of …, 2022 - mdpi.com
Peritoneal dialysis (PD) is an efficient renal replacement therapy for patients with end-stage
renal disease. Even if it ensures an outcome equivalent to hemodialysis and a better quality …

SGLT2 inhibition by intraperitoneal dapagliflozin mitigates peritoneal fibrosis and ultrafiltration failure in a mouse model of chronic peritoneal exposure to high-glucose …

MS Balzer, S Rong, J Nordlohne, JD Zemtsovski… - Biomolecules, 2020 - mdpi.com
Peritoneal dialysis (PD) is limited by glucose-mediated peritoneal membrane (PM) fibrosis,
angiogenesis, and ultrafiltration failure. Influencing PM integrity by pharmacologically …

Molecular hydrogen regulates PTEN‐AKT‐mTOR signaling via ROS to alleviate peritoneal dialysis‐related peritoneal fibrosis

H Lu, W Chen, W Liu, Y Si, T Zhao, X Lai… - The FASEB …, 2020 - Wiley Online Library
As a convenient, effective and economical kidney replacement therapy for end‐stage renal
disease (ESRD), peritoneal dialysis is available in approximately 11% of ESRD patients …

Intercellular communication in peritoneal dialysis

L Sheng, Y Shan, H Dai, M Yu, J Sun, L Huang… - Frontiers in …, 2024 - frontiersin.org
Long-term peritoneal dialysis (PD) causes structural and functional alterations of the
peritoneal membrane. Peritoneal deterioration and fibrosis are multicellular and …

TLR4 response to LPS is reinforced by urokinase receptor

Y Kiyan, S Tkachuk, S Rong, A Gorrasi… - Frontiers in …, 2020 - frontiersin.org
GPI-anchored uPAR is the receptor for the extracellular serine protease urokinase-type
plasminogen activator (uPA). Though uPAR role in inflammatory processes is documented …

Sterile inflammation of peritoneal membrane caused by peritoneal dialysis: focus on the communication between immune cells and peritoneal stroma

H Su, R Zou, J Su, X Chen, H Yang, N An… - Frontiers in …, 2024 - frontiersin.org
Peritoneal dialysis is a widely used method for treating kidney failure. However, over time,
the peritoneal structure and function can deteriorate, leading to the failure of this therapy …

Mechanisms of peritoneal mesothelial cells in peritoneal adhesion

R Wang, T Guo, J Li - Biomolecules, 2022 - mdpi.com
A peritoneal adhesion (PA) is a fibrotic tissue connecting the abdominal or visceral organs to
the peritoneum. The formation of PAs can induce a variety of clinical diseases. However …

Therapeutic mechanism of baicalein in peritoneal dialysis-associated peritoneal fibrosis based on network pharmacology and experimental validation

X Lu, K Wu, S Jiang, Y Li, Y Wang, H Li, G Li… - Frontiers in …, 2023 - frontiersin.org
Baicalein (5, 6, 7-trihydroxyflavone) is a traditional Chinese medicine with multiple
pharmacological and biological activities including anti-inflammatory and anti-fibrotic effects …