Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignancies that are
considered as a global health challenge. Despite many progresses in therapeutic methods …

Iron-dependent lipid peroxidation causes ferroptosis, a form of regulated cell death. Crucial
steps in the formation of ferroptosis include the accumulation of ferrous ions (Fe2+) and lipid …

Triple-negative breast cancer (TNBC) is considered as the most hazardous subtype of
breast cancer owing to its accelerated progression, enormous metastatic potential, and …

Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital
participant in primary cellular functions, such as proliferation, survival, migration, and …

The epithelial–mesenchymal transition (EMT) is a cellular reprogramming process that
occurs during embryonic development and adult tissue homeostasis. This process involves …

Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …

Abstract Protein arginine methyltransferase 2 (PRMT2) is involved in several biological
processes via histone methylation and transcriptional regulation. Although PRMT2 has been …

Background Bone metastasis is the leading cause of death in patients with prostate cancer
(PCa) and currently has no effective treatment. Disseminated tumor cells in bone marrow …

This comprehensive review explores vimentin as a pivotal therapeutic target in cancer
treatment, with a primary focus on mitigating metastasis and overcoming drug resistance …

Cancer stem cells (CSCs) drive tumor initiation, progression, and therapeutic resistance due
to their self-renewal and differentiation capabilities. Despite encouraging progress in cancer …