Molecular mechanisms of platelet exocytosis: insights into the “secrete” life of thrombocytes

GL Reed, ML Fitzgerald, J Polgár - Blood, The Journal of the …, 2000 - ashpublications.org
The critical role played by platelets in hemostasis, thrombosis, vascular remodeling, and
healing is related to their function as exocytotic cells that secrete important effector …

Blood platelet number and function in chronic liver disease and cirrhosis

P Witters, K Freson, C Verslype… - Alimentary …, 2008 - Wiley Online Library
Background The liver plays a central role in coagulation and fibrinolysis but is also closely
intertwined with the function and number of blood platelets. Aim To describe and integrate …

Platelets and psychiatry: lessons learned from old and new studies

A Camacho, JE Dimsdale - Psychosomatic Medicine, 2000 - journals.lww.com
Platelets play an important role not only in hemostasis but also in the pathophysiology of
coronary artery disease. The complex interactions among the vascular endothelium …

Role of platelets in neurodegenerative diseases: a universal pathophysiology

M Behari, M Shrivastava - International Journal of Neuroscience, 2013 - Taylor & Francis
Platelets play an important role in a variety of disorders, namely, cardiovascular,
psychosomatic, psychiatric, thrombosis, HIV/AIDS in addition to various neurodegenerative …

Inherited bleeding disorders: disorders of platelet adhesion and aggregation

I Ramasamy - Critical reviews in oncology/hematology, 2004 - Elsevier
Platelet aggregation at sites of vascular injury is essential for the formation of the primary
haemostatic plug. The mechanism of platelet aggregation under conditions of physiological …

4-Аminopyridine sequesters intracellular Ca2+ which triggers exocytosis in excitable and non-excitable cells

LA Kasatkina - Scientific Reports, 2016 - nature.com
aminopyridine is commonly used to stimulate neurotransmitter release resulting from
sustained plasma membrane depolarization and Ca2+-influx from the extracellular space …

Our expanding view of platelet functions and its clinical implications

C Ombrello, RC Block, CN Morrell - Journal of cardiovascular translational …, 2010 - Springer
Platelets are the primary cell mediator of thrombosis. A deficiency of platelets can result in
severe bleeding defects.“Overactive” platelets contribute to life-threatening outcomes in …

Species variability in platelet aggregation response to different agonists

A Pelagalli, P Lombardi, D d'Angelo… - Journal of comparative …, 2002 - Elsevier
Conflicting data on platelet function in animal species are reported in the literature. In this
study, the response of buffalo, horse, pig and sheep platelets to different agonists was …

Prevalence of disease and relationships between laboratory phenotype and bleeding severity in platelet primary secretion defects

LA Lotta, A Maino, G Tuana, R Rossio, A Lecchi… - PloS one, 2013 - journals.plos.org
Background The prevalence of platelet primary secretion defects (PSD) among patients with
bleeding diathesis is unknown. Moreover, there is paucity of data on the determinants of …

Impact of timing of admission and microvascular reconstruction on free flap success rates in traumatic upper extremity defects

J Kolbenschlag, M Klinkenberg… - Journal of …, 2015 - thieme-connect.com
Background Despite a growing body of knowledge, the timing of microsurgical
reconstruction for the upper extremity remains a controversial topic. Most of the available …