The prevalence of cardiovascular and metabolic disease coupled with kidney dysfunction is
increasing worldwide. This triad of disorders is associated with considerable morbidity and …

Chronic kidney disease (CKD) has a high prevalence in the general population and is
associated with high mortality; a need therefore exists for better biomarkers for diagnosis …

Chronic kidney disease is a general term for heterogeneous disorders affecting kidney
structure and function. The 2002 guidelines for definition and classification of this disease …

Abstract l-Arginine (Arg) is synthesised from glutamine, glutamate, and proline via the
intestinal-renal axis in humans and most other mammals (including pigs, sheep and rats) …

Currently, a small number of diseases, particularly cardiovascular (CVDs), oncologic (ODs),
neurodegenerative (NDDs), chronic respiratory diseases, as well as diabetes, form a severe …

Despite major advances in understanding the pathophysiology of hypertension and
availability of effective and safe antihypertensive drugs, suboptimal blood pressure (BP) …

Chronic kidney disease (CKD) is a significant worldwide healthcare problem. Regardless of
the initial injury, renal fibrosis is the common final pathway leading to end stage renal …

Aims Reduced bioavailability of endogenous nitric oxide (NO) is a central
pathophysiological event in hypertension and other cardiovascular diseases. Recently, it …

Results Most plasma amino acid concentrations were decreased in hemodialysis patients,
whereas proline, citrulline, asparagine, asymmetric dimethylarginine, and …

Asymmetric (NG, NG) dimethylarginine (ADMA) is present in plasma and cells. It can inhibit
nitric oxide synthase (NOS) that generates nitric oxide (NO) and cationic amino acid …