[HTML][HTML] Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

M Al-Azab, M Safi, E Idiiatullina, F Al-Shaebi… - Cellular & Molecular …, 2022 - Springer
Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of
differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under …

PI3K/Akt/mTOR signaling pathway in cancer stem cells

M Ebrahimi, E Nourbakhsh, AZ Hazara… - … -Research and Practice, 2022 - Elsevier
Cancer stem cells (CSCs) as a small subpopulation in tumor bulk are believed to initiate
tumor formation and are responsible for the resistance to cancer therapy. The proliferation …

[HTML][HTML] Cellular senescence in intervertebral disc aging and degeneration: molecular mechanisms and potential therapeutic opportunities

P Silwal, AM Nguyen-Thai, HA Mohammad, Y Wang… - Biomolecules, 2023 - mdpi.com
Closely associated with aging and age-related disorders, cellular senescence (CS) is the
inability of cells to proliferate due to accumulated unrepaired cellular damage and …

Curcumin-loaded mesoporous silica nanoparticles/nanofiber composites for supporting long-term proliferation and stemness preservation of adipose-derived stem …

S Mashayekhi, S Rasoulpoor, S Shabani… - International journal of …, 2020 - Elsevier
The present research aims to design and develop a sustained drug release system to
support the long-term proliferation of human adipose-derived stem cells (hADSCs) without …

Prolonged proliferation and delayed senescence of the adipose-derived stem cells grown on the electrospun composite nanofiber co-encapsulated with TiO2 …

R Pourpirali, A Mahmoudnezhad, F Oroojalian… - International journal of …, 2021 - Elsevier
This study was aimed to investigate the effects of the Poly-ε-Caprolactone/Gelatin nanofibers
(PCL/GEL NFs) co-encapsulated with TiO 2 nanoparticles (nTiO 2) and metformin-loaded …

[HTML][HTML] Mesenchymal stem cell senescence during aging: From mechanisms to rejuvenation strategies

X Jiang, W Li, L Ge, M Lu - Aging and disease, 2023 - ncbi.nlm.nih.gov
In cell transplantation therapy, mesenchymal stem cells (MSCs) are ideal seed cells due to
their easy acquisition and cultivation, strong regenerative capacity, multi-directional …

[HTML][HTML] The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway

P Li, Y Gan, Y Xu, L Song, L Wang, B Ouyang… - Scientific reports, 2017 - nature.com
Premature senescence of nucleus pulposus (NP) cells and inflammation are two common
features of degenerated discs. This study investigated the effects of the inflammatory …

In vitro expansion of human adipose-derived stem cells with delayed senescence through dual stage release of curcumin from mesoporous silica nanoparticles …

H Serati-Nouri, S Rasoulpoor, R Pourpirali… - Life Sciences, 2021 - Elsevier
Electrospun nanofibers (NFs) were utilized to realize the dual-stage release of curcumin
(Curc) to fully support the attachment, viability and proliferation of adipose-derived stem cells …

Resveratrol attenuates high glucose-induced nucleus pulposus cell apoptosis and senescence through activating the ROS-mediated PI3K/Akt pathway

W Wang, P Li, J Xu, X Wu, Z Guo, L Fan… - Bioscience …, 2018 - portlandpress.com
Background: Diabetes mellitus is closely correlated with disc degeneration. Nucleus
pulposus (NP) cell apoptosis and senescence are typical cellular features within the …

An Overview of Protocols for the Neural Induction of Dental and Oral Stem Cells In Vitro

BC Heng, LW Lim, W Wu, C Zhang - Tissue Engineering Part B …, 2016 - liebertpub.com
To date, various adult stem cells have been identified within the oral cavity, including dental
pulp stem cells, dental follicle stem cells, stem cells from apical papilla, stem cells from …