Enhancers control the establishment of spatiotemporal gene expression patterns throughout
development. Over the past decade, the development of new technologies has improved our …

The origins and the early evolution of multicellular animals required the exploitation of
holozoan genomic regulatory elements and the acquisition of new regulatory tools …

As the first line of defence against pathogens, cells mount an innate immune response,
which varies widely from cell to cell. The response must be potent but carefully controlled to …

Promoter is a fundamental DNA element located around the transcription start site (TSS) and
could regulate gene transcription. Promoter recognition is of great significance in …

Abstract ANISEED (www. aniseed. cnrs. fr) is the main model organism database for
tunicates, the sister-group of vertebrates. This release gives access to annotated genomes …

The fundamental molecular determinants by which ATP-dependent chromatin remodelers
organize nucleosomes across eukaryotic genomes remain largely elusive. Here, chromatin …

Transcription starts at genomic positions called transcription start sites (TSSs), producing
RNAs, and is mainly regulated by genomic elements and transcription factors binding …

Cytosine methylation is an ancient epigenetic modification yet its function and extent within
genomes is highly variable across eukaryotes. In mammals, methylation controls …

DNA methylation is an epigenetic mark that plays an essential role in regulating gene
expression. CpG islands are DNA methylations regions in promoters known to regulate …

DNA methylation is an epigenetic modification with a very long evolutionary history.
However, DNA methylation evolves surprisingly rapidly across eukaryotes. The genome …