DNA damage of exposed tumour tissue leading to cell death is one of the detrimental effects
of ionising radiation that is exploited, with beneficial consequences, for radiotherapy. The …

Clustered DNA lesions, also called Multiply Damaged Sites, is the hallmark of ionizing
radiation. It is defined as the combination of two or more lesions, comprising strand breaks …

When talking about research, I must mention Mrs. Rita Wagner, a superb technician that
looked after my laboratory and the younger Ph. D. students for about 25 years. Some of her …

Space programmes are shifting toward planetary exploration, and in particular towards
missions by human beings to the moon and Mars. However, exposure to space radiation is …

The accumulated evidence in the literature indicates that a cluster of two or more lesions
within one or two helical turns of the DNA is more challenging to repair than individual …

Clustered DNA damage is related to the biological effects of ionizing radiation. However, its
precise yield and complexity (ie, number of lesions per damaged site) in vivo remain …

Cellular effects of ionizing radiation (IR) are of great variety and level, but they are mainly
damaging since radiation can perturb all important components of the cell, from the …

Ionising radiation has been an important part of cancer treatment for almost a century, being
used in external-beam radiotherapy, brachytherapy, and targeted radionuclide therapy. At …

Highly regenerative tissues such as blood must possess effective DNA damage responses
(DDR) that balance long-term regeneration with protection from leukemogenesis …

A signature of ionizing radiation exposure is the induction of DNA clustered damaged sites,
defined as two or more lesions within one to two helical turns of DNA by passage of a single …