Antiparasitics acting on endo-or ectoparasites represent the second largest segment of the
global animal health market, accounting for 23% of market share. However, relatively few …

Background The world has made great strides towards beating malaria, although about half
of the world population is still exposed to the risk of contracting malaria. Developing an …

Background Recent advances in mosquito eradication and antimalarial treatments have
reduced the malaria burden only modestly. An effective malaria vaccine remains a high …

Malaria parasite infection continues to inflict extensive morbidity and mortality in resource-
poor countries. The insufficiently understood parasite biology, continuously evolving drug …

Cerebral malaria is the deadliest complication that can arise from Plasmodium infection.
CD8 T-cell engagement of brain vasculature is a putative mechanism of neuropathology in …

Transcriptomics, the analysis of genome-wide RNA expression, is a common approach to
investigate host and pathogen processes in infectious diseases. Technical and bioinformatic …

Despite the success of vaccines in preventing many infectious diseases, effective vaccines
against pathogens with ongoing challenges—such as HIV, malaria, and tuberculosis …

Malaria still affects around 200 million people and is responsible for more than 400,000
deaths per year, mostly children in subequatorial areas. This disease is caused by parasites …

Introduction: The proteasome is a multi-subunit enzyme complex responsible for the
turnover of short-lived, abnormal or damaged proteins in eukaryotic cells. As organisms that …

Abstract Evaluation of the murine isotype antibodies is essential in subunit vaccine
development because inbred mouse strains with diverse genetic backgrounds respond …