Pyoderma gangrenosum is a rare inflammatory skin disease classified within the group of
neutrophilic dermatoses and clinically characterized by painful, rapidly evolving cutaneous …

Alopecia areata (AA) is a common, inflammatory, nonscarring type of hair loss. Significant
variations in the clinical presentation of AA have been observed, ranging from small, well …

Accumulating data on cellular and molecular pathways help to develop novel therapeutic
strategies in skin inflammation and autoimmunity. Examples are psoriasis and atopic …

New molecularly targeted therapeutics are changing dermatologic therapy. Janus kinase–
signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling …

Atopic dermatitis is a common, chronic, immune-mediated disease associated with several
comorbidities. Elevated levels of T helper (Th) 2, Th22, and also some Th1 and Th17 …

Signal Transducer and Activator of Transcription (STAT) 3 has recently emerged as a key
player in the development and pathogenesis of psoriasis and psoriatic-like inflammatory …

For most inflammatory skin diseases topical glucocorticosteroids and traditional oral
immunosuppressive drugs remain the principle treatment choices, but this has started to …

The Janus kinase–signal transducer and activator of transcription pathway is a conserved
master regulator of immunity and myeloproliferation. Advanced understanding of this …

Background JTE‐052 is a novel Janus kinase inhibitor presently under clinical development
for the topical treatment of atopic dermatitis (AD). Objectives To evaluate the efficacy and …

Introduction: Psoriasis and psoriatic arthritis (PsA) are inflammatory immune-mediated
conditions which can cause considerable disability and reduced quality of life. Management …