Lichen planus (LP), an idiopathic, multifaceted chronic inflammatory disease with a
heterogeneous clinical presentation, affects approximately 0.5–1% of the population. The …

Background: Human JAKs are responsible for generating docking sites for human SSTAT
phosphorylation. The role of JAKs in psoriasis pathogenesis has not been clearly explained …

Cutaneous autoimmune and inflammatory diseases are a major burden of global disease
and many lack effective treatments that can derive in different dermatoses like atopic …

Introduction We here thought to dissect the inflammatory signature in lesions of three skin
disorders, which show a common adaptive immune response against autoantigens of the …

Cutaneous hypersensitivity reactions (CHRs) are complex inflammatory skin disorders that
affect humans and dogs. This study examined the inflammatory and immune responses …

Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that is associated with
systemic inflammatory conditions. Currently, there is no universally accepted standard …

Background The Janus kinase-signal transducer and activator of transcription signaling
pathway has been suggested as a promising therapeutic target in vitiligo. However, limited …

((1r, 4r)-4-(imidazo [4, 5-d] pyrrolo [2, 3-b] pyridin-1 (6H)-yl) cyclohexyl) acetonitrile
compounds, pharmaceutical compositions containing them, methods of making them, and …

Abstract Background: Janus kinases (JAKs) are a family of non-receptor protein tyrosine
kinases that are expressed in a variety of tissues. Several JAK-controlled cytokine receptor …

Background Janus kinase (Jak) 3 has recently been shown as a beneficial target for the
treatment of chronic inflammatory diseases, such as psoriasis and alopecia areata. The role …