A targeted effort to identify novel neurotrophic factors for midbrain dopaminergic neurons
resulted in the isolation of GDNF (glial cell line-derived neurotrophic factor) from the …

Brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor
(GDNF) are neurotrophic factors that are critical for the growth, survival, and differentiation of …

GDNF is a potent neurotrophic factor that protects catecholaminergic neurons from toxic
damage and induces fiber outgrowth. However, the actual role of endogenous GDNF in the …

Background As a more detailed picture of nervous system function emerges, diversity of
astrocyte function becomes more widely appreciated. While it has been shown that cocaine …

Purpose To prepare an angiopep-conjugated dendrigraft poly-L-lysine (DGL)-based gene
delivery system and evaluate the neuroprotective effects in the rotenone-induced chronic …

The TGF-β superfamily signaling is involved in a variety of biological processes during
embryogenesis and in adult tissue homeostasis. Faulty regulation of the signaling pathway …

The glial cell line-derived neurotrophic factor (GDNF) is a well-established trophic agent for
dopaminergic (DA) neurons in vitro and in vivo. GDNF is necessary for maintenance of …

There is clinical evidence that the symptoms of Parkinson's disease can be ameliorated by
physical exercise, and we have been using animal models to explore the hypothesis that …

Background Parkinson's disease (PD) is a progressive, neurodegenerative disorder with no
disease-modifying therapies, and symptomatic treatments are often limited by debilitating …

Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal
together or independently to fulfill many important functions in the midbrain dopaminergic …