Genetics of SLE: does this explain susceptibility and severity across racial groups?

K Demkova, DL Morris, TJ Vyse - Rheumatology, 2023 - academic.oup.com
The prevalence and severity of SLE have been found to vary across populations of different
ancestries. This review explores whether these differences can be explained by the genetic …

[HTML][HTML] Evaluating machine learning-powered classification algorithms which utilize variants in the GCKR gene to predict metabolic syndrome: Tehran Cardio …

M Akbarzadeh, N Alipour, H Moheimani… - Journal of Translational …, 2022 - Springer
Abstract Background Metabolic syndrome (MetS) is a prevalent multifactorial disorder that
can increase the risk of developing diabetes, cardiovascular diseases, and cancer. We …

[HTML][HTML] Atopic polygenic risk score is associated with paradoxical eczema developing in patients with psoriasis treated with biologics

A Al-Janabi, S Eyre, AC Foulkes, AR Khan… - Journal of Investigative …, 2023 - Elsevier
Biologic therapies for psoriasis can cause paradoxical eczema. The role of genetic factors in
its pathogenesis is unknown. To identify risk variants, we conducted a GWAS of 3,212 …

[HTML][HTML] A survey of genome-wide association studies, polygenic scores and UK Biobank highlights resources for autoimmune disease genetics

R Saurabh, CJK Fouodo, IR König, H Busch… - Frontiers in …, 2022 - frontiersin.org
Autoimmune diseases share a general mechanism of auto-antigens harming tissues. Still.
they are phenotypically diverse, with genetic as well as environmental factors contributing to …

Genes and sales

S Gong, Q Li, S Su, J Zhang - Management Science, 2023 - pubsonline.informs.org
This paper presents one of the first marketing applications of molecular genetics. We report
evidence that salespeople's genetic variants linked to educational attainment predict sales …

A multi-ancestry genetic study of pain intensity in 598,339 veterans

S Toikumo, R Vickers-Smith, Z Jinwala, H Xu, D Saini… - Nature Medicine, 2024 - nature.com
Chronic pain is a common problem, with more than one-fifth of adult Americans reporting
pain daily or on most days. It adversely affects the quality of life and imposes substantial …

[HTML][HTML] AmelHap: Leveraging drone whole-genome sequence data to create a honey bee HapMap

M Parejo, A Talenti, M Richardson, A Vignal, M Barnett… - Scientific Data, 2023 - nature.com
Honey bee, Apis mellifera, drones are typically haploid, developing from an unfertilized egg,
inheriting only their queen's alleles and none from the many drones she mated with. Thus …

Supergenes as drivers of ant evolution

M Chapuisat - Myrmecological News, 2023 - biotaxa.org
Ants show striking diversity in social organization, raising major questions on the proximate
and ultimate causes of such variation. The shift from one-queen (= monogyne) societies to …

[PDF][PDF] CNest: A novel copy number association discovery method uncovers 862 new associations from 200,629 whole-exome sequence datasets in the UK Biobank

T Fitzgerald, E Birney - Cell Genomics, 2022 - cell.com
Copy number variation (CNV) is known to influence human traits, having a rich history of
research into common and rare genetic disease, and although CNV is accepted as an …

Natural polymorphisms in ZMET2 encoding a DNA methyltransferase modulate the number of husk layers in maize

Z Wang, A Xia, Q Wang, Z Cui, M Lu, Y Ye… - Plant …, 2024 - academic.oup.com
DNA methylation affects agronomic traits and the environmental adaptability of crops, but the
natural polymorphisms in DNA methylation–related genes and their contributions to …