Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions

S Fatumo, D Sathan, C Samtal, I Isewon, T Tamuhla… - Genome medicine, 2023 - Springer
Early identification of genetic risk factors for complex diseases can enable timely
interventions and prevent serious outcomes, including mortality. While the genetics …

Identifying the mediating role of socioeconomic status on the relationship between schizophrenia and major depressive disorder: a Mendelian randomisation analysis

Q Xu, M Cai, Y Ji, J Ma, J Liu, Q Zhao, Y Chen, Y Zhao… - Schizophrenia, 2023 - nature.com
Depressive disorder prevalence in patients with schizophrenia has been reported to be
40%. People with low socioeconomic status (SES) are more likely to suffer from …

Current uses and future perspectives of genomic technologies in clinical microbiology

I Bianconi, R Aschbacher, E Pagani - Antibiotics, 2023 - mdpi.com
Recent advancements in sequencing technology and data analytics have led to a
transformative era in pathogen detection and typing. These developments not only expedite …

Acknowledging lack of inclusion in genetic analyses—reply

ME Benros, RL Allesøe, S Rasmussen - JAMA psychiatry, 2023 - jamanetwork.com
In Reply We appreciate the correspondence from Pariyadath1 about the extremely important
point of having broad inclusion criteria for the results to be as generalizable as possible. We …

Integrated metabolomics and transcriptomics reveal metabolic patterns in retina of STZ-induced diabetic retinopathy mouse model

R Wang, Q Jian, G Hu, R Du, X Xu, F Zhang - Metabolites, 2022 - mdpi.com
Diabetic retinopathy (DR), as the leading cause of vision loss in the working-age population,
exhibits unique metabolite profiles in human plasma and vitreous. However, those in retina …

Challenges and Opportunities for Data Science in Women's Health

TL Edwards, CA Greene, JA Piekos… - Annual Review of …, 2023 - annualreviews.org
The intersection of women's health and data science is a field of research that has
historically trailed other fields, but more recently it has gained momentum. This growth is …

Genetic Determinants of Atherogenic Indexes

T Texis, S Rivera-Mancía, E Colín-Ramírez… - Genes, 2023 - mdpi.com
Atherogenesis and dyslipidemia increase the risk of cardiovascular disease, which is the
leading cause of death in developed countries. While blood lipid levels have been studied …

[HTML][HTML] Examining the biological mechanisms of human mental disorders resulting from gene-environment interdependence using novel functional genomic …

PP Silveira, MJ Meaney - Neurobiology of Disease, 2023 - Elsevier
We explore how functional genomics approaches that integrate datasets from human and
non-human model systems can improve our understanding of the effect of gene …

Genotype Data and Derived Genetic Instruments of Adolescent Brain Cognitive Development Study® for Better Understanding of Human Brain Development

CC Fan, R Loughnan, S Wilson, JK Hewitt… - Behavior genetics, 2023 - Springer
The data release of Adolescent Brain Cognitive Development®(ABCD) Study represents an
extensive resource for investigating factors relating to child development and mental …

[HTML][HTML] Comparison of multiple imputation algorithms and verification using whole-genome sequencing in the CMUH genetic biobank

TY Liu, CF Lin, HT Wu, YL Wu, YC Chen, CC Liao… - Biomedicine, 2021 - ncbi.nlm.nih.gov
A genome-wide association study (GWAS) can be conducted to systematically analyze the
contributions of genetic factors to a wide variety of complex diseases. Nevertheless, existing …