[HTML][HTML] Deep learning for genomics: from early neural nets to modern large language models

T Yue, Y Wang, L Zhang, C Gu, H Xue, W Wang… - International Journal of …, 2023 - mdpi.com
The data explosion driven by advancements in genomic research, such as high-throughput
sequencing techniques, is constantly challenging conventional methods used in genomics …

[HTML][HTML] Identification of QTL associated with resistance to Phytophthora fruit rot in cucumber (Cucumis sativus L.)

YC Lin, BN Mansfeld, X Tang, M Colle… - Frontiers in Plant …, 2023 - frontiersin.org
Phytophthora fruit rot (PFR) caused by the soilborne oomycete pathogen, Phytophthora
capsici, can cause severe yield loss in cucumber. With no resistant variety available, genetic …

[HTML][HTML] Perturbational phenotyping of human blood cells reveals genetically determined latent traits associated with subsets of common diseases

M Homilius, W Zhu, SS Eddy, PC Thompson… - Nature Genetics, 2024 - nature.com
Although genome-wide association studies (GWAS) have successfully linked genetic risk
loci to various disorders, identifying underlying cellular biological mechanisms remains …

Identification of genetic risk factors for monogenic and complex canine diseases

T Leeb, D Bannasch… - Annual Review of Animal …, 2023 - annualreviews.org
Advances in DNA sequencing and other technologies have greatly facilitated the
identification of genetic risk factors for inherited diseases in dogs. We review recent …

[HTML][HTML] Vetinformatics from functional genomics to drug discovery: insights into decoding complex molecular mechanisms of livestock systems in veterinary science

RK Pathak, JM Kim - Frontiers in Veterinary Science, 2022 - frontiersin.org
Having played important roles in human growth and development, livestock animals are
regarded as integral parts of society. However, industrialization has depleted natural …

[PDF][PDF] The phenotype-genotype reference map: Improving biobank data science through replication

L Bastarache, S Delozier, A Pandit, J He… - The American Journal of …, 2023 - cell.com
Population-scale biobanks linked to electronic health record data provide vast opportunities
to extend our knowledge of human genetics and discover new phenotype-genotype …

[HTML][HTML] A human leukocyte antigen imputation study uncovers possible genetic interplay between gut inflammatory processes and autism spectrum disorders

L Lombardi, S Le Clerc, CL Wu, J Bouassida… - Translational …, 2023 - nature.com
Autism spectrum disorders (ASD) are neurodevelopmental conditions that are for subsets of
individuals, underpinned by dysregulated immune processes, including inflammation …

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

R van Der Meer, SA Mohamed, VM Monpellier… - Obesity …, 2023 - Wiley Online Library
The extent to which genetic variations contribute to interindividual differences in weight loss
and metabolic outcomes after bariatric surgery is unknown. Identifying genetic variants that …

[HTML][HTML] Evidence of shared genetic factors in the etiology of gastrointestinal disorders and endometriosis and clinical implications for disease management

F Yang, Y Wu, R Hockey, J Doust, GD Mishra… - Cell Reports …, 2023 - cell.com
In clinical practice, the co-existence of endometriosis and gastrointestinal symptoms is often
observed. Using large-scale datasets, we report a genetic correlation between …

[HTML][HTML] Omics approaches in invasion biology: understanding mechanisms and impacts on ecological health

S Qi, J Wang, Y Zhang, M Naz, MR Afzal, D Du, Z Dai - Plants, 2023 - mdpi.com
Invasive species and rapid climate change are affecting the control of new plant diseases
and epidemics. To effectively manage these diseases under changing environmental …