Background Nicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in
every living cell, is involved in a myriad of metabolic processes associated with cellular …

Sirt1 is the most prominent and extensively studied member of sirtuins, the family of
mammalian class III histone deacetylases heavily implicated in health span and longevity …

Neurodegenerative diseases are a group of pathological conditions that cause motor inc-
ordination (jerking movements), cognitive and memory impairments result from …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

Sirtuins are NAD‐dependent protein deacetylases known to have protective effects against
age‐related diseases such as cancer, diabetes, cardiovascular and neurodegenerative …

The question whether dietary habits and lifestyle have influence on the course of multiple
sclerosis (MS) is still a matter of debate, and at present, MS therapy is not associated with …

Intracranial aneurysm subarachnoid hemorrhage (SAH) is a cerebrovascular disorder
associated with high overall mortality. Currently, the underlying mechanisms of pathological …

Aging is the predominant risk factor for neurodegenerative diseases. One key phenotype as
the brain ages is an aberrant innate immune response characterized by proinflammation …

Hippocampus is one of the most vulnerable brain regions in terms of age-related
pathological change. Exercise is presumed to delay the aging process and promote health …

It is generally considered that Parkinson's disease is induced by specific agents that
degenerate a clearly defined population of dopaminergic neurons. Data commented in this …