Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Abstract Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most
abundant protein in excitatory synapses and is central to synaptic plasticity, learning and …

Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, has revolutionized the
treatment of depression because of its potent, rapid and sustained antidepressant effects …

Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

Antiseizure drugs (ASDs) prevent the occurrence of seizures; there is no evidence that they
have disease-modifying properties. In the more than 160 years that orally administered …

Clinical studies have demonstrated that a single sub-anesthetic dose of the dissociative
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …

Hundreds of studies have found that weak magnetic fields can significantly influence various
biological systems. However, the underlying mechanisms behind these phenomena remain …

Abstract The calcium ion (Ca2+) is a universal signal in all eukaryotic cells. A fundamental
question is how Ca2+, a simple cation, encodes complex information with high specificity …

Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as
a key neuromodulator to control synapse and circuit function over a wide range of spatial …