Investigations into the mixed muscle–secretory phenotype of cardiomyocytes from the atrial
appendages of the heart led to the discovery that these cells produce, in a regulated …

Natriuretic peptides, which are activated in heart failure, play an important cardioprotective
role. The most notable of the cardioprotective natriuretic peptides are atrial natriuretic …

The adult zebrafish heart has a high capacity for regeneration following injury. However, the
composition of the regenerative niche has remained largely elusive. Here, we dissected the …

Cardiac natriuretic peptides (NPs), atrial NP (ANP) and B-type NP (BNP) are true hormones
produced and released by cardiomyocytes, exerting several systemic effects. Together with …

Definition γ-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the
central nervous system. Structures involved in releasing and binding GABA as a …

Heart failure (HF) with preserved ejection fraction (HFpEF) is currently the predominant form
of HF with a dramatic increase in risk with age. Low‐grade inflammation, as occurs with …

Congestive heart failure (HF) is a complex disease state characterized by impaired
ventricular function and insufficient peripheral blood supply. The resultant reduced blood …

Antioxidants are molecules characterized by function rather than common structural motifs.
Their common feature is the capability of acting “anti”-oxidants in biological systems. Owing …

The myocardium consists of different cell types, of which endothelial cells, cardiomyocytes,
and fibroblasts are the most abundant. Communication between these different cell types …

Cardiovascular diseases have become a major clinical burden globally. Heart failure is one
of the diseases that commonly emanates from progressive uncontrolled hypertension. This …