Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …

The past decade has seen an explosion in the identification of genetic causes of
neurodevelopmental disorders, including Mendelian, de novo, and somatic factors. These …

Autism spectrum disorder (ASD) is a phenotypically heterogeneous neurodevelopmental
disorder that affects an estimated 1 in 44 children in the United States (1). ASD prevalence …

There is no clear genetic etiology or convergent pathophysiology for autism spectrum
disorders (ASD). Using induced pluripotent stem cell (iPSC)-derived brain organoids and …

Autism is a heritable and common neurodevelopmental condition, with behavioural
symptoms typically emerging around age 2 to 3 years. Differences in basic perceptual …

Gene expression covaries with brain activity as measured by resting state functional
magnetic resonance imaging (MRI). However, it is unclear how genomic differences driven …

The tissue-specific expression and epigenetic dysregulation of many genes in cells derived
from the postmortem brains of patients have been reported to provide a fundamental …

Abstract Noncoding RNAs (ncRNAs) occupy~ 98% of the transcriptome in human, and are
usually not translated into proteins. Among ncRNAs, long non-coding RNAs (lncRNAs,> 200 …

Autism spectrum disorder (ASD) is a highly heterogeneous disorder, yet transcriptomic
profiling of bulk brain tissue has identified substantial convergence among dysregulated …

Epileptic seizures are distinct but frequent comorbidities in children with autism spectrum
disorder (ASD). The hyperexcitability of cortical and subcortical neurons appears to be …