Pancreatic cancer is a devastating gastrointestinal cancer characterized by late diagnosis,
limited treatment success and dismal prognosis. Exocrine tumours account for 95% of …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a prominent extracellular
matrix (ECM) deposition and poor prognosis. High levels of ECM proteins derived from …

Nowadays, a large population around the world, especially the elderly, suffers from
neurological inflammatory and degenerative disorders/diseases. Current drug delivery …

Gemcitabine (GEM) resistance is a major challenge for chemotherapy of pancreatic cancer.
Previous studies have reported on the role of long noncoding RNA (lncRNA) in …

The energy metabolism of tumor cells is considered one of the hallmarks of cancer because
it is different from normal cells and mainly consists of aerobic glycolysis, fatty acid oxidation …

Pancreatic cancer is a lethal disease with limited opportunity for resectable surgery as the
first choice for cure due to its late diagnosis and early metastasis. The desmoplastic stroma …

Immunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC),
contributing to early metastasis and poor patient survival. Compared to the localized tumors …

Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is
characterized by poor treatment response and low survival time. The current clinical …

Although FOXD1 has been found to be involved in the malignant processes of several types
of cancers, its role in pancreatic cancer (PC) is not well understood. This study aimed to …

It has been long recognized that cancer cells reprogram their metabolism under hypoxia
conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to …